Dth |
| カタログ番号GC91440 |
Dthは、RNAの蛍光プローブであるDFHBIと免疫調節化合物であるサリドマイドから構成されたプロテオリシスターゲティングキメラ（PROTAC）です。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Dth is a proteolysis-targeting chimera (PROTAC) composed of the fluorescent probe for RNA DFHBI and the immunomodulatory compound thalidomide .1 It binds to a genetically expressed RNA aptamer comprising Broccoli and a modifiable and selective protein targeting sequence and induces degradation of mCherry in HEK293T cells when used at a concentration of 20 µM. Dth (20 µM) induces degradation of the NF-κB subunit p50, as well as p50 and the E2F transcription factor subtype E2F1, in MCF-7 cells.
Review for Dth
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
Review for Dth
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