E7449 mesylate - 2X-121 |
| カタログ番号GB40190 |
E7449メシル酸塩は、PARP1/2およびtankyrase1/2の強力な脳浸透性かつ経口生物利用可能な二重阻害剤であり、DNA修復欠損腫瘍の増殖を抑制し、Wntシグナリングを拮抗します。 E7449メシル酸塩は、PARP1とPARP2に対してそれぞれIC50値が2.0nMおよび1.0nMを示します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1140965-47-4
Sample solution is provided at 25 µL, 10mM.
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E7449 mesylate is a potent, brain penetrable and orally bioavailable dual inhibitor of PARP1/2 and tankyrase1/2, which inhibits growth of DNA repair deficient tumors and antagonizes Wnt signalling. E7449 mesylate exhibits IC50 values of 2.0 and 1.0 nM for PARP1 and PARP2, respectively.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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