E7766 diammonium salt |
| カタログ番号GC62608 |
E7766 ジアンモニウム塩は、Kd が 40 nM の大環状分子架橋 STING アゴニストです。 E7766 ジアンモニウム塩は、強力な汎遺伝子型および抗腫瘍活性を示します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2242635-03-4
Sample solution is provided at 25 µL, 10mM.
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E7766 diammonium salt is a macrocycle-bridged STING agonist with a Kd of 40 nM. E7766 diammonium salt shows potent pan-genotypic and antitumor activities[1].
E7766 diammonium salt inhibits four human STING variants, human wild-type, HAQ, AQ and REF STING proteins, with EC50 values of 1 μM, 2.2 μM, 1.2 μM and 4.9 μM, respectively[1].
In murine colon cancer model, a single intratumoral injection of 10 mg/kg E7766 diammonium salt in the subcutaneous tumor. E7766 diammonium salt is shown to have potent antitumor activity with long lasting immune memory response in a mouse liver metastatic tumor model[1].
[1]. Dae-Shik Kim, et al. E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity. ChemMedChem. 2021 Jun 7;16(11):1740-1743.
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