EBOV/MARV-IN-1 |
| カタログ番号GC60799 |
EBOV/MARV-IN-1 はエボラ ウイルス (EBOV) およびマールブルグ ウイルス (MARV) の強力な阻害剤であり、幅広い活性 (それぞれ EC50=0.31 および 0.82 μM) と低い細胞毒性 (SI>100) を備えています。 HeLa細胞で。
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Cas No.: 2479465-67-1
Sample solution is provided at 25 µL, 10mM.
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EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV), with broad-spectrum activity (EC50=0.31, and 0.82 µM, respectively) and low cytotoxicity (SI>100) in HeLa cells[1].
EBOV/MARV-IN-1 (12.5 µM; 48 h) inhibits HIV/EBOV-GP (EC50=12 nM) and HIV/MARV-GP (EC50=180 nM) pseudotype virus in A549 cells containing a luciferase reporter gene, with low cytotoxicity (SI =2088)[1].
[1]. Gaisina IN, et, al. Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections. J Med Chem. 2020 Jul 9;63(13):7211-7225.
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