EED226-COOH |
| カタログ番号GC60147 |
EED226-COOHは、EED226由来の標的タンパク質のリガンドである PROTACのEEDリガンドは、リンカーを介してVHLのリガンドと結合し、UNC6852を形成してPRC2を分解します。
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Cas No.: 2467965-71-3
Sample solution is provided at 25 µL, 10mM.
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EED226-COOH is an EED226-derived ligand for target protein EED ligand for PROTAC, binds to a ligand for VHL via linker to form UNC6852 to degrade PRC2[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Potjewyd F, et al. Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15.
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