ENPP1 Inhibitor C |
| カタログ番号GC46138 |
ENPP1 阻害剤 C (化合物 C) は、TG-mAMP、pNP-TMP、および ATP アッセイによってそれぞれ評価された 0.26、0.48、および 2.0 μM の IC50 値を持つ強力な ENPP1 (エクトヌクレオチド ピロホスファターゼ/ホスホジエステラーゼ 1) 阻害剤です。 TG (Tokyo Green)-mAMP: 新しく合成された感度の高い ENPP1 蛍光プローブ。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2378640-92-5
Sample solution is provided at 25 µL, 10mM.
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ENPP1 inhibitor C is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50 = 0.26 μM in a cell-free assay).1 It is selective for ENPP1 over ENPP2-7 at 10 μM. ENPP1 inhibitor C decreases ENPP1 activity in MDA-MB-231 human breast and C6 rat glioma cancer cells when used at a concentration of 10 μM.
|1. Kawaguchi, M., Han, X., Hisada, T., et al. Development of an ENPP1 fluorescence probe for inhibitor screening, cellular imaging, and prognostic assessment of malignant breast cancer. J. Med. Chem. 62(20), 9254-9269 (2019).
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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