ホーム>>Lipids>> Reactive O2/N2 Pathways>>ent-8-iso Prostaglandin F2α-d9

ent-8-iso Prostaglandin F2α-d9 (Synonyms: ent-8-epi PGF2αd9, ent-8-iso PGF2αd9, ent-15-F2t-Isoprostane-d9)

カタログ番号GC47292

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ent-8-iso Prostaglandin F2α-d9 化学構造

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サイズ 価格 在庫数 個数
10 μg
$221.00
在庫あり
25 μg
$524.00
在庫あり
50 μg
$996.00
在庫あり
100 μg
$1,767.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description of ent-8-iso Prostaglandin F2α-d9

ent-8-iso-Prostaglandin F-d9 (ent-8-iso-PGF-d9) contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19',20,20, and positions. It is intended for use as an internal standard for the quantification of ent-8-iso-PGF by GC- or LC-mass spectrometry. Isoprostanes are produced by the non-enzymatic, free-radical peroxidation of arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have a potent biological activity. ent-8-iso Prostaglandin F (ent-8-iso PGF) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 31 and 54 nM, respectively.1

1.Hou, X., Robers, L.J., II, Gobeil, F., Jr., et al.Isomer-specific contractile effects of a series of synthetic F2-isoprostanes on retinal and cerebral microvasculatureFree Radical Biology & Medicine36(2)163-172(2004)

Chemical Properties of ent-8-iso Prostaglandin F2α-d9

Cas No. N/A SDF
同義語 ent-8-epi PGF2αd9, ent-8-iso PGF2αd9, ent-15-F2t-Isoprostane-d9
Canonical SMILES O[C@H](C[C@H](O)[C@H]1/C=C/[C@H](O)CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])[C@@H]1C/C=C\CCCC(O)=O
Formula C20H25D9O5 M.Wt 363.5
溶解度 DMF: >100 mg/ml,DMSO: >100 mg/ml,Ethanol: >100 mg/ml,PBS (pH 7.2): 3 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of ent-8-iso Prostaglandin F2α-d9

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.751 mL 13.7552 mL 27.5103 mL
5 mM 0.5502 mL 2.751 mL 5.5021 mL
10 mM 0.2751 mL 1.3755 mL 2.751 mL
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In vivo Formulation Calculator (Clear solution) of ent-8-iso Prostaglandin F2α-d9

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Average Rating: 5 ★★★★★ (Based on Reviews and 22 reference(s) in Google Scholar.)

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