EP1013 (F1013) (Synonyms: F1013) |
| カタログ番号GC31390 |
EP1013 (F1013) (F1013) は、1 型糖尿病の研究に使用される広域スペクトルのカスパーゼ選択的阻害剤です。
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Cas No.: 223568-55-6
Sample solution is provided at 25 µL, 10mM.
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EP1013 is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.
EP1013 (1, 3, 10 mg/kg) significantly improves marginal islet mass function. Two animals in the 10 mg/kg EP1013 treatment group exhibit primary islet graft nonfunction, but the diabetes reversalrate for this group is not significantly different from the 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD groups. EP1013 therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function[1].
[1]. Emamaullee JA, et al. The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice. Diabetes. 2008 Jun;57(6):1556-66.
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