ErSO-DFP |
| カタログ番号GC65425 |
ErSO-DFP は、予測的展開タンパク質応答 (a-UPR) アクティベーターです。 ErSO-DFP は、ErSO よりも広い選択範囲で、エストロゲン受容体アルファ陽性（ERα+）がん細胞に対する選択性を高めています。ErSO-DFP は抗腫瘍活性を示し、マウスモデルで MCF-7 腫瘍の深刻な退縮をもたらします。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2768139-76-8
Sample solution is provided at 25 µL, 10mM.
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ErSO-DFP is an anticipatory unfolded protein response (a-UPR) activator. ErSO-DFP has enhanced selectivity for estrogen receptor alpha-positive (ERα+) cancer cells with a wider selectivity window than ErSO.ErSO-DFP displays antitumor activity and leads to profound regression of MCF-7 tumors in mice model[1].
[1]. Matthew W Boudreau, et al. Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer. J Med Chem. 2022 Mar 10;65(5):3894-3912.
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