Fentiazac |
| カタログ番号GC70465 |
Fentiazacアルカン酸誘導体は経口活性非ステロイド抗炎症薬であり、鎮痛、解熱、抗血小板凝集活性を有する。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 18046-21-4
Sample solution is provided at 25 µL, 10mM.
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Fentiazac is well tolerated after repeated oral administration in rats, monkeys and dogs; and no significant modifications in the heart and bone marrow function, as well as blood chemistry[1].
Tolerance of Fentiazac in rat, monkey and dog[1].
| Species | Tolerant dosage | Tolerant administration day |
| Rat | 0-50 mg/kg/day | 90 days |
| Red pated monkey | 40 mg/kg/day | 90 days |
| 0-30 mg/kg/day | 180 days | |
| African green monkey | 0-8 mg/kg/day | 79 to 93 days |
| dog | 16.6 mg/kg/day | 180 days |
References:
[1]. Emilio Marmo, et al. Experimental and clinical pharmacology of fentiazac, a new, non-steroidal anti-inflammatory agent. Current Medical Research and Opinion.Volume 6, 1979 - Issue sup2.
[2]. Gabor Katona, et al. Efficacy and tolerability of fentiazac in rheumatoid arthritis: Double-blind study versus indomethacin. Current Medical Research and Opinion. Volume 6, 1979 - Issue sup2.
[3]. Famaey JP, Gaci O, Ginsberg F. Fentiazac in the treatment of osteoarthritis and tendinitis. Curr Med Res Opin. 1983;8(9):675-81.
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