Ferritin PROTAC DeFer-2 |
| カタログ番号GC91060 |
フェリチンの分解を促進するPROTAC
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Ferritin PROTAC DeFer-2 is a proteolysis-targeting chimera (PROTAC) containing oleic acid , which binds to ferritin dimers, conjugated to von Hippel-Lindau ligand , which binds to VHL E3 ligase, via an alkyl linker.1 It induces ferritin degradation in B16/F10 murine melanoma cells when used at a concentration of 0.5 µM, an effect not induced by a negative control with an inverted VHL ligand 1 stereocenter, indicating that the E3 ligase activity of VHL ligand 1 is required for this effect. Ferritin PROTAC DeFer-2 (5 µM) increases intracellular levels of free iron and induces pyroptosis in B16/F10 cells. Ferritin PROTAC De-Fer-2 (10 mg/kg) encapsulated in albumin nanoparticles reduces tumor growth and increases survival in a B16/F10 murine melanoma model.
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