FGIN-1-27 |
| カタログ番号GC14017 |
FGIN-1-27、インドールアセトアミドは、5.0 nM の Ki を持つ特定の末梢ベンゾジアゼピン受容体 (PBR) リガンドです。
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Cas No.: 142720-24-9
Sample solution is provided at 25 µL, 10mM.
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FGIN-1-27 is an indoleacetamide that acts as a high affinity agonist of the 18 kDa translocator protein (TSPO; previously called the peripheral benzodiazepine receptor) with a Ki value of 5 nM.1 It can enhance steroidogenesis of neuroactive steroids such as allopregnanolone.[1] Through this action, FGIN-1-27 indirectly potentiates GABAA receptor signaling to produce anticonvulsant, anxiolytic, and sedative activity in both animal and clinical models.[1]
Reference:
[1]. James, M.L., Selleri, S., and Kassiou, M. Development of ligands for the peripheral benzodiazepine receptor. Current Medicinal Chemistry 13(17), 1991-2001 (2006).
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