FPH2 (BRD-9424) (Synonyms: FPH2, Functional Poliferation Hit 2) |
| カタログ番号GC14677 |
FPH2 (BRD-9424) は初代ヒト肝細胞の機能的増殖を誘導し、肝疾患の新しい治療法の開発につながる可能性があります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 957485-64-2
Sample solution is provided at 25 µL, 10mM.
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FPH2 (BRD-9424) is an inducer of functional proliferation of primary human hepatocytes [1].
Human hepatocytes are capable of extensive expansion. With partial hepatectomy, the residual hepatocytes are able to proliferate and replace lost liver mass [1].
FPH2 (BRD-9424) is an inducer of proliferation of primary human hepatocytes. In vitro, FPH2 induced functional proliferation of hepatocytes and might be useful for expanding mature human primary hepatocytes. In human primary hepatocytes, FPH2 increased the number of nuclei undergoing mitosis and hepatocyte nuclei count in a concentration dependent way. Also, FPH2 (40 μM) increased the area of hepatocyte colonies with more hepatocytes and Ki67-positive nuclei, which exhibited hepatocyte nuclear morphologies. In primary human hepatocytes from six additional cell sources, FPH2 increased hepatocytes expansion. FPH2 increased hepatocyte at a rate that is consistent with liver regeneration kinetics in vivo [1].
Reference:
[1]. Shan J, Schwartz RE, Ross NT, et al. Identification of small molecules for human hepatocyte expansion and iPS differentiation. Nat Chem Biol, 2013, 9(8): 514-520.
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