G140 |
| カタログ番号GC62664 |
G140 は、サイクリック GMP-AMP シンターゼ (cGAS) の強力かつ選択的な阻害剤であり、h-cGAS および m-cGAS の IC50 はそれぞれ 14.0nM および 442nM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2369751-07-3
Sample solution is provided at 25 µL, 10mM.
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G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively. G140 has anti-inflammatory activity[1].
G140 (0.1-100 µM; 4 h) inhibits h-cGAS in a dose-dependent manner with IC50s of 1.70 and 0.86 µM in human THP1 and primary macrophages, respectively[1].G140 (0.1-100 µM; 24 h) inhibits cells viability with a LD50 of >100 µM in THP1 cells[1].
[1]. Lama L, et, al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21; 10(1): 2261.
| Cas No. | 2369751-07-3 | SDF | |
| Formula | C17H16Cl2N4O2 | M.Wt | 379.24 |
| 溶解度 | DMSO : 250 mg/mL (659.21 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.6369 mL | 13.1843 mL | 26.3685 mL |
| 5 mM | 0.5274 mL | 2.6369 mL | 5.2737 mL |
| 10 mM | 0.2637 mL | 1.3184 mL | 2.6369 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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