G3-C12 |
| カタログ番号GC34174 |
G3-C12 は 88 nM の Kd を持つガレクチン 3 結合ペプチドであり、抗癌活性を示します。
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Cas No.: 848301-94-0
Sample solution is provided at 25 µL, 10mM.
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G3-C12 is a galectin-3 binding peptide, with Kd of 88 nM, and shows anticancer activity.
G3-C12 is a galectin-3 binding peptide, with high affinity (Kd) of 88 nM, but shows no affinity for other galectin family members or to other lectins. G3-C12 bearing opolymers N-(2-hydroxypropyl)methacrylamide (HPMA) potently and selectively targets colorectal cancer (CRC) tumour cells over-expressing galectin-3 and displays superior targetability to galectin-3 compared to the galactose bearing copolymer[1].
[1]. Kopansky E, et al. Peptide-directed HPMA copolymer-doxorubicin conjugates as targeted therapeutics for colorectal cancer. J Drug Target. 2011 Dec;19(10):933-43.
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