Boc-Gly-Arg-Arg-AMC |
カタログ番号GA21012 |
Boc-Gly-Arg-Arg-AMCは、ウェストナイルウイルスプロテアーゼ、黄熱病ウイルスNS3プロテアーゼ、およびデング熱ウイルスNS2B-NS3プロテアーゼなどのフラビウイルスプロテアーゼの基質です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 113866-14-1
Sample solution is provided at 25 µL, 10mM.
Boc-Gly-Arg-Arg-AMC is a substrate for flavivirus proteases such as West Nile virus protease, yellow fever virus NS3 protease, and dengue virus NS2B-NS3 protease. Boc-GRR-AMC is cleaved by type II Metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana. Stock solutions of Boc-GRR-AMC are best prepared in DMSO [1-2].
References:
[1]. Osman H, Idris NH, et,al. 3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors. Acta Pharm Sin B. 2017 Jul;7(4):479-484. doi: 10.1016/j.apsb.2017.04.009. Epub 2017 May 4. PMID: 28752033; PMCID: PMC5518655.
[2]. Abduraman MA, Hariono M, et,al. Development of a NS2B/NS3 protease inhibition assay using AlphaScreen® beads for screening of anti-dengue activities. Heliyon. 2018 Dec 8;4(12):e01023. doi: 10.1016/j.heliyon.2018.e01023. PMID: 30560214; PMCID: PMC6289942.
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