GalNAc unconjugated/naked Fitusiran sodium |
| カタログ番号GC71122 |
GalNAc unconjugated/naked Fitusiran sodium 、GalNAc結合のない小さな干渉RNA、抗トロンビンATシグナリングRNAを特異的に標的化し、肝臓中のATの産生を低下させる。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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GalNAc unconjugated/naked Fitusiran (sodium), an small interfering RNA without GalNAc conjugation, specifically targets antithrombin (AT) messenger RNA to lower production of AT in the liver. Fitusiran increases thrombin generation and has the potential for the research of the hemophilia.
References:
[1]. Pasi KJ, et al. Targeting of antithrombin in hemophilia A or B with investigational siRNA therapeutic fitusiran-Results of the phase 1 inhibitor cohort.J Thromb Haemost. 2021;19(6):1436-1446.
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