GBLD 345 |
| カタログ番号GC16495 |
GABAA受容体アゴニスト
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 122479-08-7
Sample solution is provided at 25 µL, 10mM.
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GBLD 345 is a potent agonist of benzodiazepine receptor.
Benzodiazepine receptor is an allosteric modulatory site on GABAA receptor [1]. The GABAA receptor is a ligand-gated ion channel and activated by γ-aminobutyric acid (GABA). The GABAA receptor selectively permits Cl- through its pore and results in hyperpolarization of the neuron, which causes an inhibitory effect on neurotransmission.
GBLD 345 is a potent benzodiazepine receptor agonist with IC50 value of 1 nM against diazepam.
Reference:
[1]. Sieghart W. Pharmacology of benzodiazepine receptors: an update. J Psychiatry Neurosci, 1994, 19(1): 24-29.
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