Dehydroeffusol |
| カタログ番号GC35834 |
Dehydroeffusol は、薬草 Juncus effuses からのフェナントレンです。 Dehydroeffusol は、腫瘍抑制性小胞体ストレスと中等度のアポトーシスを選択的に誘導することにより、胃癌細胞の増殖と腫瘍原性を阻害します。非常に低い毒性を示します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 137319-34-7
Sample solution is provided at 25 µL, 10mM.
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Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. It shows very low toxicity[1][2].
Dehydroeffusol suppresses the expression of vasculogenic mimicry key gene VE-cadherin[2].Dehydroeffusol decreases the MMP2 expression and activity in gastric cancer cells[2].
[1]. Zhang B, et al. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. Biochem Pharmacol. 2016 Mar 15;104:8-18. [2]. Liu W, et al. Dehydroeffusol effectively inhibits human gastric cancer cell-mediated vasculogenic mimicry with low toxicity. Toxicol Appl Pharmacol. 2015 Sep 1;287(2):98-110.
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