dMCL1-2 |
| カタログ番号GC35882 |
dMCL1-2 は、30 nM の KD で MCL1 に結合するセレブロンに基づく、骨髄細胞性白血病 1 (MCL1) (Bcl-2 ファミリーのメンバー) の強力かつ選択的な PROTAC です。 dMCL1-2 は、MCL1 の分解によって細胞アポトーシス機構を活性化します。
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Cas No.: 2351218-88-5
Sample solution is provided at 25 µL, 10mM.
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dMCL1-2 is a potent and selective degrader of myeloid cell leukemia 1 (MCL1) based on PROTAC, which binds to MCL1 with a KD of 30 nM. dMCL1-2 activats the cellular apoptosis machinery by degradation of MCL1[1]. KD: 30 nM (MCL1)[1]
[1]. Papatzimas JW, et al. From Inhibition to Degradation: Targeting the Antiapoptotic Protein Myeloid Cell Leukemia 1 (MCL1). J Med Chem. 2019 Jun 13;62(11):5522-5540.
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