E3 ligase Ligand 13 |
| カタログ番号GC35927 |
E3 リガーゼ リガンド 13 は、E3 ユビキチン リガーゼのリガンドです。 E3 リガーゼ リガンド 13 は、リンカーによってタンパク質のリガンドに接続され、PROTAC を形成します。 PROTAC は、がん促進タンパク質のユビキチン化を介した分解のインデューサーです。
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Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 13 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 13 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.
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