Indirubin-5-sulfonate |
| カタログ番号GC36313 |
インジルビン-5-スルホネートは、CDK1/サイクリン B、CDK2/サイクリン A、CDK2/サイクリン E の IC50 値が 55 nM、35 nM、150 nM、300 nM、65 nM のサイクリン依存性キナーゼ (CDK) 阻害剤です。それぞれ CDK4/サイクリン D1、および CDK5/p35。インジルビン-5-スルホネートは、GSK-3β に対しても阻害活性を示します。
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Cas No.: 244021-67-8
Sample solution is provided at 25 µL, 10mM.
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Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively[1]. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β[2]. Cdk1/cyclin B|55 nM (IC50)|cdk2/cyclin A|35 nM (IC50)|CDK2/cyclinE|150 nM (IC50)|Cdk4/cyclin D1|300 nM (IC50)|CDK5/p35|65 nM (IC50)|GSK-3β
[1]. Hoessel R, et al. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol. 1999 May;1(1):60-7. [2]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors• J Biol Chem. 2001 Jan 5;276(1):251-60.
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