INT-777 R-enantiomer (Synonyms: S-EMCA R enantiomer) |
| カタログ番号GC36319 |
INT-777 R-エナンチオマーは INT-777 の R-エナンチオマーであり、TGR5 の EC50 は 4.79 μM であり、INT-777 よりも強力ではありません。
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Cas No.: 1198786-98-9
Sample solution is provided at 25 µL, 10mM.
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INT-777 (R-enantiomer) is the R-enantiomer of INT-777, with EC50 of 4.79 μM for TGR5, and less potent than INT-777.
INT-777 (R-enantiomer) is more choleretic than CA (4), but less than INT-777[1].
[1]. Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61.
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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