JNJ-37822681 dihydrochloride |
| カタログ番号GC36370 |
JNJ-37822681 二塩酸塩は、ドーパミン D2L 受容体に対して中程度の結合親和性 (Ki = 158 nM) を有する、強力で特異的、中枢活性、高速解離性ドーパミン D2 受容体アンタゴニストであり、統合失調症および双極性障害の治療の可能性があります [1 ]。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2108806-02-4
Sample solution is provided at 25 µL, 10mM.
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JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder[1]. Ki: 158 nM (dopamine D(2))[1]
[1]. Langlois X, et al. Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia. J Pharmacol Exp Ther. 2012 Jul;342(1):91-105.
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