ML367 |
カタログ番号GC36630 |
ML367 は、ATPase ファミリー AAA ドメイン含有タンパク質 5 (ATAD5) 安定化の強力な阻害剤であり、低マイクロモル阻害活性を持つプローブ分子として機能します。 ML367 は DNA 修復経路をブロックし、UV 照射に応答した RPA32 リン酸化および CHK1 リン酸化を含む一般的な DNA 損傷応答を抑制します。
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Cas No.: 381168-77-0
Sample solution is provided at 25 µL, 10mM.
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation[1]. ATAD5[1]
ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd[1]. Western Blot Analysis[1] Cell Line: HEK293T cells
[1]. Rohde JM, et al. Discovery of ML367, inhibitor of ATAD5 stabilization. Probe Reports from the NIH Molecular Libraries Program.
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