ML-792 |
| カタログ番号GC36631 |
ML-792 は、NAE/NEDD8 および UAE/ユビキチン (IC50 値 32 μM および >100 μM) と比較して、酵素アッセイにおける SAE/SUMO1 および SAE/SUMO2 の強力かつ選択的な阻害剤 (それぞれ 3 および 11 nM の IC50 値) です。 、 それぞれ）。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1644342-14-2
Sample solution is provided at 25 µL, 10mM.
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ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50s of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μM, respectively)[1].
[1]. He X, et al. Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor. Nat Chem Biol. 2017 Nov;13(11):1164-1171.
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