MMV008138 |
カタログ番号GC36637 |
MMV008138 は、種選択的な IspD (酵素 2-C-メチル-d-エリスリトール 4-リン酸シチジルトランスフェラーゼ) を標的とする抗マラリア薬であり、PfIspD の IC50 は 44 nM です (P.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1679333-73-3
Sample solution is provided at 25 µL, 10mM.
MMV008138 is a species-selective antimalarial agent which targets the enzyme 2- C-methyl-d-erythritol 4-phosphate cytidylyltransferase (IspD) in the MEP pathway, with an IC50 of 250 nM for P. falciparum Dd2 strain[1][2]. IC50: 250 nM (P. falciparum Dd2 strain)[1]
[1]. Ghavami M, et al. Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3 S)-MMV008138 and Analogs. ACS Infect Dis. 2018 Apr 13;4(4):549-559. [2]. Yao ZK, et al. Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1515-9.
Average Rating: 5
(Based on Reviews and 19 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *