Oteseconazole (Synonyms: VT-1161) |
カタログ番号GC36822 |
オテセコナゾール (VT-1161) は、経口活性抗真菌剤であり、Candida albicans CYP51 (Kd、<39 nM) に強力に結合して阻害しますが、ヒト CYP51 には明らかな影響を示しません 。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1340593-59-0
Sample solution is provided at 25 µL, 10mM.
Oteseconazole (VT-1161) is an orally active anti-fungal agent, potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM), shows no obvious effect on human CYP51[1][2].
[1]. Warrilow AG, et al. The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. Antimicrob Agents Chemother. 2014 Dec;58(12):7121-7. [2]. Garvey EP, et al. VT-1161 dosed once daily or once weekly exhibits potent efficacy in treatment of dermatophytosis in a guinea pig model. Antimicrob Agents Chemother. 2015 Apr;59(4):1992-7.
Average Rating: 5
(Based on Reviews and 34 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *