PF-04937319 |
カタログ番号GC36881 |
PF-04937319 は、EC50 値が 154.4 μM のグルコキナーゼ活性化因子 (GKA) であり、2 型糖尿病の治療において最も有望な戦略の 1 つです 。
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Cas No.: 1245603-92-2
Sample solution is provided at 25 µL, 10mM.
PF-04937319 is a glucokinase activator (GKA) with EC50 value of 154.4 μM, one of the most promising strategies for the treatment of type 2 diabetes mellitus[1].PF-04937319 is designed to maintain glucose-lowering efficacy while mitigating the risk of hypoglycaemia observed with many other GKAs[2]. EC50: 154.4 μM (GSA) (PF-04937319)[1]
[1]. Dzyurkevich MS, et al. Pyridoxine dipharmacophore derivatives as potent glucokinase activators for the treatment of type 2 diabetes mellitus. Sci Rep. 2017 Nov 22;7(1):16072. [2]. Amin NB, et al. Two dose-ranging studies with PF-04937319, a systemic partial activator of glucokinase, as add-on therapy to metformin in adults with type 2 diabetes. Diabetes Obes Metab. 2015 Aug;17(8):751-9.
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