Proadrenomedullin (1-20), human |
| カタログ番号GC36970 |
プロアドレノメデュリン (1-20)、ヒトは、クロム親和性細胞から放出される強力な降圧性およびカテコールアミン放出阻害ペプチドであり、PC12 褐色細胞腫細胞におけるカテコールアミン分泌の IC50 は約 350 nM であり、特にニコチン性コリン作動性受容体で非競合的に作用します [1 ]。
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Cas No.: 150238-87-2
Sample solution is provided at 25 µL, 10mM.
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Proadrenomedullin (1-20), human is a potent hypotensive and catecholamine release-inhibitory peptide released from chromaffin cells with an IC50 of ~350 nM for catecholamine secretion in PC12 pheochromocytoma cells, acting in a noncompetitive manner specifically at the nicotinic cholinergic receptor[1].
[1]. Mahata M, et al. Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors. Hypertension. 1998 Nov;32(5):907-16.
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