PTD-p65-P1 Peptide |
| カタログ番号GC37036 |
PTD-p65-P1 ペプチドは、強力な選択的核転写因子 NF-κB 阻害剤であり、NF-κB アミノ酸残基 271-282 の p65 サブユニットに由来し、さまざまな炎症性刺激によって誘導される NF-κB 活性化を選択的に阻害します。 NF-κB を介した遺伝子発現を調節し、アポトーシスをアップレギュレートします。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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PTD-p65-P1 Peptide is a nuclear transcription factor NF-kappaB inhibitor, composed of a membrane-translocating peptide sequence generated from antennapedia (PTD) conjugated with p65-P1, which selectively inhibits activation induced by various inflammatory stimuli[1]. NF-kappaB[1]
[1]. Takada Y, et al. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J Biol Chem. 2004 Apr 9;279(15):15096-104.
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