RU.521 (Synonyms: RU-320521) |
| カタログ番号GC37570 |
RU.521 (RU320521) は、強力かつ選択的なサイクリック GMP-AMP シンターゼ (cGAS) 阻害剤であり、cGAS を介したインターフェロンのアップレギュレーションを阻害します。
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Cas No.: 2262452-06-0
Sample solution is provided at 25 µL, 10mM.
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RU.521 (RU320521) is a potent dsDNA and cGAS inhibitor with an IC50 of 700 nM for dsDNA. RU.521 inhibits cGAS-mediated interferon upregulation and suppresses dsDNA-dependent activation. RU.521 is active and selective in cellular assays of cyclic GMP-AMP synthase-mediated signaling and reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-GoutiÈres syndrome (AGS)[1]. IC50: 700 nM (dsDNA)[1]
[1]. Vincent J, et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750.
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