Seltorexant (Synonyms: JNJ-42847922) |
| カタログ番号GC37623 |
セルトレキサント (JNJ-42847922) は、経口活性、高親和性、選択的オレキシン 2 受容体 (OX2R) 拮抗薬です (ヒトおよびラット OX2R の pKi 値は 8.0 および 8.1)。
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Cas No.: 1293281-49-8
Sample solution is provided at 25 µL, 10mM.
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Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1]. pKi: 8.0 (human OX2R), 8.1 (rat OX2R)[1]
[1]. Bonaventure P, et al. Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia. J Pharmacol Exp Ther. 2015 Sep;354(3):471-82.
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