TAS4464 |
| カタログ番号GC37742 |
TAS4464は、NEDD8活性化酵素（NAE）の非常に強力で選択的な阻害剤であり、IC50値は0.955 nMです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1848959-10-3
Sample solution is provided at 25 µL, 10mM.
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TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM[1]. IC50:0.955 nM (NAE)[1]
TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines.
References:
[1]. Yoshimura C, et al. TAS4464, a highly potent and selective inhibitor of NEDD8 activating enzyme, suppresses neddylation and shows antitumor activity in diverse cancer models. Mol Cancer Ther. 2019 May 15.
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