Tigloylgomisin H |
| カタログ番号GC37791 |
Tigloylgomisin H は、S. chinensis の果実から分離されたリグナンであり、Hepa1c1c7 マウス肝癌細胞でキノン還元酵素 (QR) 活性を誘導することができます。チグロイルゴミシン H は、NF-E2 関連因子 2 (Nrf2)-ARE 経路を介して第 II 相解毒酵素 NQO1 を特異的にアップレギュレートする単機能性インデューサーとして機能するため、潜在的な肝臓がん予防剤となります。
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Cas No.: 66069-55-4
Sample solution is provided at 25 µL, 10mM.
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Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent[1].
[1]. Lee SB, et al. Induction of the phase II detoxification enzyme NQO1 in hepatocarcinoma cells by lignans from the fruit of Schisandra chinensis through nuclear accumulation of Nrf2. Planta Med. 2009 Oct;75(12):1314-8.
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