Tubulysin |
| カタログ番号GC37835 |
二次代謝産物のチューブリシン ファミリーは、もともと粘液細菌 Archangium geophyra および Angiococcus disciformis から分離されています。これらの化合物は、多剤耐性特性を持つものを含む多くの癌細胞株に対してピコモル範囲の IC50 値を持つ強力な微小管不安定化剤です。チューブリシンは重度の毒性のために治療上の有用性が限られているため、チューブリシンは分子薬物複合体 (SMDC) 送達システムに組み込まれる理想的な候補です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1943604-24-7
Sample solution is provided at 25 µL, 10mM.
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Tubulysin family of secondary metabolites are originally isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. These compounds are potent microtubule destabilizing agents with IC50 values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties. Tubulysins have limited therapeutic utility due to severe toxicity, so Tubulysins are ideal candidates to be incorporated into molecule drug conjugate (SMDC) delivery system[1].
[1]. Leamon CP, et al. Prostate-Specific Membrane Antigen-Specific Antitumor Activity of a Self-Immolative Tubulysin Conjugate. Bioconjug Chem. 2019 Jun 19;30(6):1805-1813.
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