UK 356618 |
| カタログ番号GC38530 |
MMP-3の阻害剤
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 230961-08-7
Sample solution is provided at 25 µL, 10mM.
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UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) with an IC50 of 5.9 nM. UK 356618 is >140-fold less potent against MMP-1 (IC50 of 51,000 nM), MMP-2 (IC50 of 1790 nM), MMP-9 (IC50 of 840 nM) and MMP-14 (IC50 of 1900 nM) compared with MMP-3[1].
[1]. Fray MJ, et al. Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1). Bioorg Med Chem Lett. 2001 Feb 26;11(4):571-4.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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