Demethylwedelolactone (Synonyms: DWL, Norwedelolactone, 1,3,8,9-Tetrahydroxycoumestan) |
| カタログ番号GC38576 |
デメチルウェデロラクトンは、Eclipta alba から分離された天然のクメスタンです。デメチルウェデロラクトンは、IC50 が 3.0 μM の強力なトリプシン阻害剤です。脱メチルウェデロラクトンは、乳癌細胞の細胞運動と細胞浸潤を抑制します。
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Cas No.: 6468-55-9
Sample solution is provided at 25 µL, 10mM.
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Demethylwedelolactone is a naturally occurring coumestan isolated from Eclipta alba. Demethylwedelolactone is a potent trypsin inhibitor with an IC50 of 3.0 μM. Demethylwedelolactone suppresses cell motility and cell invasion of breast cancer cell[1][2].
[1]. Syed SD, et al. Trypsin inhibitory effect of wedelolactone and demethylwedelolactone. Phytother Res. 2003 Apr;17(4):420-1. [2]. Lee YJ, et al. Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice. Eur J Med Chem. 2012 Oct;56:361-7.
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