4-Hydroxychalcone (Synonyms: 2-Benzal-4'-hydroxyacetophenone, 2-Benzylidene-4'-hydroxyacetophenone, p-Cinnamoylphenol, NSC 242264) |
| カタログ番号GC38663 |
4-ヒドロキシカルコンは、抗血管新生および抗炎症活性を持つカルコン代謝産物です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 20426-12-4
Sample solution is provided at 25 µL, 10mM.
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4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].
[1]. Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691(1-3):125-33. [2]. Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415.
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