Pogostone

Pogostone is a pyranone that has been found in the essential oil of P. cablin, also known as patchouli oil, and has antifungal and insecticidal activities.1 It is active against a laboratory strain and clinical isolates of C. albicans (MICs = 49 and 12-97 μg/ml, respectively). It reduces fungal load in the vagina in a mouse model of fluconazole-resistant vulvovaginal candidiasis when administered at topical doses of 1, 2, and 4 mg/kg per day or oral doses of 20, 40, and 80 mg/kg per day.2 Pogostone is toxic to S. exigua and S. litura larvae with LC50 values of 545.61 and 986.88 mg/L for dietary administration and 519.48 and 1,041.42 mg/L for contact application.3 It also has antifeedant activity against third instar larvae against S. exigua and S. litura.

References
1. Yi, Y.-Y., He, J.-J., Su, J.-Q., et al. Synthesis and antimicrobial evaluation of pogostone and its analogues. Fitoterapia 84, 135-139 (2013).
2. Li, Y.-C., Liang, H.-C., Chen, H.-M., et al. Anti-Candida albicans activity and pharmacokinetics of pogostone isolated from Pogostemonis Herba. Phytomedicine 20(1), 77-83 (2012).
3. Huang, S.-H., Xian, J.-D., Kong, S.-Z., et al. Insecticidal activity of pogostone against Spodoptera litura and Spodoptera exigua (Lepidoptera: Noctuidae). Pest Manag. Sci. 70(3), 510-516 (2014).