8-Isopentenylnaringenin (Synonyms: 8-PN)

In rabbit bone marrow cells, (卤)-8-Prenylnaringenin inhibits the formation and induces apoptosis of Osteoclasts to a greater extent than naringenin. (卤)-8-Prenylnaringenin is applied to the MC3T3-E1 osteoblast cell line, where it enhances differentiation and maturation, and also inhibits the differentiation of the RAW264.7 osteoclast cell line. (卤)-8-Prenylnaringenin inhibits the expression of receptor activator of nuclear factor-魏B ligand (RANKL), and leads to increased expression of osteoprotegerin^[1].
A significant, dose-dependent inhibition of proliferation is observed in PC-3 human prostate cancer cells and UO.31 human renal carcinoma cells after exposure to (卤)-8-Prenylnaringenin. In MCF-10A, a human breast cancer cell line, (卤)-8-Prenylnaringenin modulats the metabolic pathways of estradiol conversion into cancer-promoting metabolites, and thereby inhibits malignant transformation^[1].

(卤)-8-Prenylnaringenin (50 mg/kg; orally gavage; once daily; for 12 days) ameliorates impaired glucose homeostasis and islet dysfunction induced by STZ treatment. (卤)-8-Prenylnaringenin increases the protein expression levels of ER伪 in the pancreas and liver and of fibroblast growth factor 21 in the liver^[3].

[1]. Kate艡ina 艩tul铆kov谩, et al. Therapeutic Perspectives of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops. Molecules. 2018 Mar 15;23(3):660.  

[2]. Frederik Roelens, et al. Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen receptors alpha and beta. J Med Chem. 2006 Dec 14;49(25):7357-65.  

[3]. Song Park, et al. Naringenin and Phytoestrogen 8-Prenylnaringenin Protect against Islet Dysfunction and Inhibit Apoptotic Signaling in Insulin-Deficient Diabetic Mice. Molecules. 2022 Jun 30;27(13):4227.