Flunarizine |
カタログ番号GF11514 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 52468-60-7
Sample solution is provided at 25 µL, 10mM.
Flunarizine blocks sodium currents (INa) and calcium currents (ICa) with IC50 values of 0.94 渭M and 1.77 渭M in cultured rat cortical neurons, respectively[2].
Flunarizine (10 and 30 渭M; 24 h) shows cytotoxic effects to chromaffin cells[4].
Flunarizine (1-30 渭M) causes clear cytoprotection of chromaffin cell at concentrations of 3-10 渭M[4].
Flunarizine (intraperitoneal injection; 30鈥塵g/kg; once) protects mice from lipopolysaccharide- (LPS-) induced acute lung injury (ALI)[5].
[1]. Hong-Seob So, et al. Protective effect of T-type calcium channel blocker flunarizine on cisplatin-induced death of auditory cells. Hear Res. 2005 Jun;204(1-2):127-39.
[2]. Qing Ye, et al. Flunarizine blocks voltage-gated Na(+) and Ca(2+) currents in cultured rat cortical neurons: A possible locus of action in the prevention of migraine. Neurosci Lett. 2011 Jan 10;487(3):394-9.
[3]. Celia M Santi, et al. Differential inhibition of T-type calcium channels by neuroleptics. J Neurosci. 2002 Jan 15;22(2):396-403.
[4]. Novalbos J, et al. Effects of dotarizine and flunarizine on chromaffin cell viability and cytosolic Ca2+. Eur J Pharmacol. 1999 Feb 5;366(2-3):309-17.
[5]. Wan L, et al. Mibefradil and Flunarizine, Two T-Type Calcium Channel Inhibitors, Protect Mice against Lipopolysaccharide-Induced Acute Lung Injury. Mediators Inflamm. 2020 Nov 10;2020:3691701.
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