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7,3',4'-Trihydroxy-3-benzyl-2H-chromene

カタログ番号GF18557

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7,3',4'-Trihydroxy-3-benzyl-2H-chromene 化学構造

Cas No.: 1111897-60-9

サイズ 価格 在庫数 個数
1mg
$217.00
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Sample solution is provided at 25 µL, 10mM.

Description of 7,3',4'-Trihydroxy-3-benzyl-2H-chromene

7,3',4'-Trihydroxy-3-benzyl-2H-chromene is an reversible noncompetitive neuraminidase (NA) inhibitor. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be isolated from the dried heartwood of Caesalpinia sappan L. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene has potent NAs inhibitory activities with IC50 values of 34.6 碌M [H1N1], 39.5 碌M [H3N2], and 50.5碌M [H9N2], respectively. 7,3',4'-Trihydroxy-3-benzyl-2H-chromene can be used for the research of influenza virus.

7,3',4'-Trihydroxy-3-benzyl-2H-chromene (Compound 11) has potent NAs inhibitory activities with IC50 values of 34.6 碌M [H1N1], 39.5 碌M [H3N2], and 50.5 碌M [H9N2], respectively[1].

[1]. Hyung Jae Jeong, et al. Homoisoflavonoids from Caesalpinia sappan displaying viral neuraminidases inhibition. Biol Pharm Bull. 2012;35(5):786-90.  

[2]. Huanxin Zhao, et al. A new homoisoflavan from Caesalpinia sappan. J Nat Med. 2008 Jul;62(3):325-7. 

Chemical Properties of 7,3',4'-Trihydroxy-3-benzyl-2H-chromene

Cas No. 1111897-60-9 SDF
Formula C16H14O4 M.Wt 270.28
溶解度 DMSO : 100 mg/mL (369.99 mM; Need ultrasonic) Storage 2-8°C, sealed storage,away from moisture
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 7,3',4'-Trihydroxy-3-benzyl-2H-chromene

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.6999 mL 18.4993 mL 36.9987 mL
5 mM 0.74 mL 3.6999 mL 7.3997 mL
10 mM 0.37 mL 1.8499 mL 3.6999 mL
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**ストックソリューションを準備する際には、常にバイアルラベルおよび MSDS/CoA(オンラインで利用可能)で掲載された製品のロット固有分子量を使用してください。

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In vivo Formulation Calculator (Clear solution) of 7,3',4'-Trihydroxy-3-benzyl-2H-chromene

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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