Ghrelin (rat) (palmitoyl) (trifluoroacetate salt) |
| カタログ番号GC43753 |
グレリンは内因性の消化管ホルモンおよび神経ペプチドであり、成長ホルモン（GH）分泌促進受容体（GHS-R）に結合します。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R). Ghrelin requires an n-octanoyl modification at serine 3 for binding to GHS-R. Ghrelin (rat) (palmitoyl) is a palmitoylated form of ghrelin. Palmitoylated ghrelin is an agonist of GHS-R with a similar potency as octanoyl-ghrelin in HEK293 cells expressing human GHS-R1a (IC50 = 0.87 nM; EC50 = 8.3 nM for increasing calcium accumulation). In mice, palmitoylated ghrelin (0.9 nmol, i.c.v.) increases food intake after 24 hours but not at shorter timepoints of two and four hours. It also increases fat mass without effects on locomotor activity or energy expenditure.
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