Glucocerebrosides (Gaucher's spleen) (Synonyms: Ganglioside GL1a, Gaucher cerebroside, GluCers (Gaucher's spleen), Glucocerebrosides, Glucosylceramides (Gaucher's spleen)) |
| カタログ番号GC43768 |
グルコシルセラミド合成酵素によって、グルコースがセラミドに結合してグルコセレブロシドが形成されます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 85305-87-9
Sample solution is provided at 25 µL, 10mM.
Glucocerebrosides are formed by the tethering of glucose to a ceramide by glucosylceramide synthase. They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of plant species. Glucocerebrosides are precursors in the synthesis of lactosylceramides and gangliosides. Increased levels of glucocerebrosides are associated with obesity-induced insulin resistance in mice and with neuronal deficits observed in neuronopathic Gaucher disease. This product is a mixture of glucocerebrosides, with variable ceramide chain lengths, isolated from a spleen of a human with Gaucher's disease.
| Cas No. | 85305-87-9 | SDF | |
| 同義語 | Ganglioside GL1a, Gaucher cerebroside, GluCers (Gaucher's spleen), Glucocerebrosides, Glucosylceramides (Gaucher's spleen) | ||
| Canonical SMILES | O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC([R])=O)[C@@H]1O | ||
| Formula | C48H93NO8 (for lignoceryl) | M.Wt | 812.3 |
| 溶解度 | Chloroform:Methanol (2:1): soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.2311 mL | 6.1554 mL | 12.3107 mL |
| 5 mM | 0.2462 mL | 1.2311 mL | 2.4621 mL |
| 10 mM | 0.1231 mL | 0.6155 mL | 1.2311 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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