Glutaric acid |
| カタログ番号GC33814 |
グルタル酸、C5 ジカルボン酸は、リジンとトリプトファンの異化経路の中間体です。
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Cas No.: 110-94-1
Sample solution is provided at 25 µL, 10mM.
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Glutaric acid induces oxidative stress in brain of young rats.
Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM[1].
[1]. de Oliveira Marques F, et al. acid induces oxidative stress in brain of young rats. Brain Res. 2003 Feb 21;964(1):153-8.
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