Glycerophospho-N-Eicosapentaenoyl Ethanolamine (Synonyms: GP-NEPEA) |
| カタログ番号GC43775 |
N-アシル化されたエタノールアミン（NAE）は、多様な生物活性を持つ天然の脂質です。
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Sample solution is provided at 25 µL, 10mM.
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N-Acylated ethanolamines (NAEs) are naturally-occurring lipids that have diverse bioactivities. For example, arachidonoyl ethanolamide is an endogenous neurotransmitter that evokes cellular responses by activating the cannabinoid (CB) receptors, central CB1 and peripheral CB2. The different types of NAEs are derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1. Glycerophospho-N-eicosapentaenoyl ethanolamine is the metabolic precursor of eicosapentaenoyl ethanolamide . EPEA is an NAE that inhibits dietary-restriction-induced lifespan extension in wild type and TOR pathway mutant nematodes. EPEA also has anti-inflammatory properties, suppressing the expression of IL-6 and MCP-1 in 3T3-L1 adipocytes in response to lipopolysaccharide.
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