GPI-16552 (Synonyms: N-bis-(3-Phenyl-propyl)-9-oxo-fluorene-2,7-diamide) |
カタログ番号GB40221 |
GPI-16552(443794-40-9)は、ポリ(ADPリボース)グリコヒドロラーゼ(PARG)の新しい強力な阻害剤であり、IC50 = 1.7μMです。 GPI-16552による虚血前または虚血後の治療(40 mg / kg)は、脳虚血ラットモデルにおける脳梗塞体積を減少させます。それは、ラット腹部動脈閉塞モデルにおける虚血/再灌流の炎症反応を調節し、実験的な脊髄外傷後の脊髄炎症と組織損傷度を低下させます。 GPI-16552はテモゾロマイドと相乗作用してB16メラノーマ細胞が注入されたマウスでメラノーマ細胞浸潤と転移拡大を減少させます。
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Cas No.: 443794-40-9
Sample solution is provided at 25 µL, 10mM.
GPI-16552 (443794-40-9) is a novel potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), IC50=1.7 μM. Pre or post ischemia treatment (40 mg/kg) with GPI-16552 reduces brain infarct volumes in a rat model of cerebral ischemia. It modulates the inflammatory response to ischemia/reperfusion in a rat splanchnic artery occlusion model and reduces the degree of spinal cord inflammation and tissue injury after experimental spinal cord trauma. GPI-16552 synergizes with temozolomide in decreasing melanoma cell invasion and metastatic spreading in mice injected with B16 melanoma cells.
Average Rating: 5
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