HB007 |
| カタログ番号GC63002 |
HB007 は小さなユビキチン関連修飾子 1 (SUMO1) デグレーダーです。 HB007 は SUMO1 のユビキチン化と分解を誘導し、in vivo での腫瘍増殖を抑制します。 HB007 は、脳、乳、結腸、および肺がんの研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2387821-46-5
Sample solution is provided at 25 µL, 10mM.
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HB007 is a small ubiquitin-related modifier 1 (SUMO1) degrader. HB007 induces ubiquitination and degradation of SUMO1, resulting in reduced tumor growth in vivo. HB007 can be used for the research of brain, breast, colon, and lung cancers[1][2].
HB007 (compound 24) (0.1-100 μM) inhibits LN229 cell growth in a concentration-dependent manner t[1].HB007 (10-25 μM) reduces SUM01 conjugation and total protein levels of SUM01 but not SUM02/3 or UB in LN229 cells t[1].
HB007 (compound 24) (25-50 mg/kg; i.p. for 15 d) significantly suppresses tumor growth of colon and lung cancer but had no effect on the body weights of mice[1].
[1]. Bellail AC, et, al. Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors. Sci Transl Med. 2021 Oct 13;13(615):eabh1486.
[2]. BELLAIL A, et, al. Compositions and methods for treating cancer. WO2019217509A1.
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