Histone H3K27Me3 (23-34) (human, mouse, rat, bovine) (trifluoroacetate salt) (Synonyms: Lys(Me3)27-Histone H3 (23-34), Histone H3 (23-34) (Lys27me3), KAAR-K(Me3)-SAPATGG) |
| カタログ番号GC43851 |
Histone H3K27Me3（23-34）は、ヒトヒストンH3.1およびH3.2配列のアミノ酸残基24-35に対応するヒストンH3のペプチドフラグメントです。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Histone H3K27Me3 (23-34) is a peptide fragment of histone H3 that corresponds to amino acid residues 24-35 of the human histone H3.1 and H3.2 sequences. Trimethylation of histone H3 at lysine 27 is associated with gene silencing. It is involved in tumor progression through its regulation by enhancer of zeste homolog 2 (EZH2) and transcriptional repression of tumor suppressor genes. Levels of H3K27Me3 are reduced in 293 T-REx cells containing EEDR236T and SUZ12G610V mutations and in lymphoblastoid cells isolated from patients with Weaver syndrome, a rare overgrowth disorder characterized by EZH2, EED, or SUZ12 mutations, cancer susceptibility, and various distinctive physical features. Histone H3K27Me3 (23-34) has been used in AlphaLISA® assays to verify antibody specificity.
| Cas No. | SDF | ||
| 同義語 | Lys(Me3)27-Histone H3 (23-34), Histone H3 (23-34) (Lys27me3), KAAR-K(Me3)-SAPATGG | ||
| Canonical SMILES | C[N+](CCCC[C@H](NC([C@@H](NC([C@H](C)NC([C@H](C)NC([C@@H](N)CCCCN)=O)=O)=O)CCCNC(N)=N)=O)C(N[C@H](C(N[C@@H](C)C(N1CCC[C@H]1C(N[C@@H](C)C(N[C@]([H])(C(NCC(NCC([O-])=O)=O)=O)[C@H](O)C)=O)=O)=O)=O)CO)=O)(C)C.O=C(O)C(F)(F)F | ||
| Formula | C49H89N17O15•XCF3COOH | M.Wt | 1156.3 |
| 溶解度 | Water: 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.8648 mL | 4.3241 mL | 8.6483 mL |
| 5 mM | 0.173 mL | 0.8648 mL | 1.7297 mL |
| 10 mM | 0.0865 mL | 0.4324 mL | 0.8648 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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